Comitato direttivo
Giovanni F. Accolla, Franco Cardini, Domenico Del Nero, Giordano Bruno Guerri, Gennaro Malgieri, Gennaro Sangiuliano, Mirella Serri, Marcello Veneziani.
Un nuovo tipo di farmaco ha prolungato la vita di alcuni pazienti affetti da melanoma in una sperimentazione clinica, aggiungendo potenzialmente un numero crescente di terapie per una malattia che un tempo era quasi incurabile.
"Nella malattia del melanoma, stiamo vivendo qualcosa di incredibile," dice la Dr. Caroline Robert, ricercatore principale dello studio terapico, dopo una conferenza stampa al meeting dell'American Society of Clinical Oncology svoltasi a New York domenica 3 giugno.
Il nuovo farmaco, GlaxoSmithLine 's trametinib, ha ulteriormente ridotto il progredire della malattia rispetto alla chemioterapia, ha dichiarato sempre la Dr. Robert, che è a capo dell’ Institut Gustave Roussy di Villejuif, di dermatologia in Francia.
Mentre il melanoma, se diagnosticato precocemente, di solito può essere curato chirurgicamente rimuovendo la lesione cutanea , è sempre stato molto difficile da trattare, invece, una volta che si diffonde in altre parti del corpo.
Ma l'anno scorso due farmaci, che prolungano la vita di questi pazienti molto malati, hanno ricevuto l'approvazione normativa.
Uno di loro, Yervoy , da Bristol-Myers Squibb, consente al sistema immunitario di attaccare meglio il cancro . L'altro, Zelboraf, da Roche e Daiichi Sankyo, blocca l'effetto di una mutazione in gene chiamato BRAF. La mutazione, presente in circa la metà dei casi di melanoma, spinge il tumore alla crescita.
Lo Zelboraf funziona bene per molti pazienti, ma il tumore può alla fine diventare resistente al farmaco. Inoltre, il BRAF può causare tumori secondari della pelle, che non sono così gravi come il melanoma e può essere rimosso chirurgicamente, ma sono comunque indesiderabili esteticamente, soprattutto per le donne, ha tenuto a precisare la Dr. Robert, che è anche un consulente Glaxo e di altre compagnie.
Il Trametinib, è una pillola, che viene somministrata solo ai pazienti con la mutazione BRAF. Ma, essa, blocca una proteina chiamata MEK che è appena a valle del BRAF, nella catena di segnali, che stimolano la crescita tumorale.
Il Blocco MEK potrebbe essere un’ alternativa al blocco BRAF, e non provoca i tumori cutanei secondari. Alcuni primi risultati suggeriscono che gli inibitori del BRAF e gli inibitori MEK potrebbero essere utilizzati insieme.
La Glaxo sta sviluppando il suo proprio inibitore BRAF, dabrafenib e risultati degli studi clinici di questo farmaco sono anche stato presentati nel corso di questo meeting dal Dr. Paolo Paoletti, presidente della divisione di oncologia Glaxo, il quale ha riferito che la società sta provvedendo a normativizzare l'approvazione di entrambi i farmaci nel prossimo futuro.
Il processo trametinib, sponsorizzato dalla Compagnia Glaxo e condotto lo scorso anno, ha coinvolto 322 pazienti con melanoma avanzato o metastatico che hanno ricevuto come cura uno dei due farmaci chemioterapici.
Il tempo medio prima che la malattia peggiorasse è stato di 4,8 mesi per il trametinib, rispetto al mese e mezzo ottenuto con la chemioterapia.
Dopo sei mesi, l'81 per cento di quelli trattati col trametinib erano sopravvissuti rispetto al 67 per cento di quelli appartenenti al gruppo di chemioterapia.
La sopravvivenza è aumentata anche nella metà dei pazienti che, sottoposti a chemioterapia, sono poi passati al trattamento con il trametinib quando la malattia aveva iniziato a peggiorare.
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Custom Silicone Ice Lattice 2 Iron Pipe Fittings ジャカルタブランドコピー
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Small Silver Aluminum Watch Box 本当に届くブランドコピー店届かない Plastic Film Packaging
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Inserito da Arc Lever Waterproof Micro Lever il 20/04/2023 01:48:06
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Inserito da 9" Cutting Discs il 11/04/2023 19:50:01
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Inserito da Home Air Purifier il 07/04/2023 07:28:08
Plastic Waterproof Junction Enclosure https://seabuzz.in/ Home Air Purifier
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Inserito da Residential Metal Garage Buildings il 17/03/2023 16:49:22
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Inserito da Power Drum Auger il 13/03/2023 04:13:22
Inserito da 10KV Insulation Piercing Connector il 09/03/2023 10:26:42
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Inserito da Silicon Rubber Tri-clamp Santary Gasket il 07/03/2023 04:29:56
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Inserito da シャネルスーパーコピー il 04/03/2023 02:32:33
Inserito da シャネルブレスレットコピー il 27/02/2023 08:36:15
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Inserito da Camping Carts il 27/02/2023 06:22:58
Inserito da Forging Machine il 27/02/2023 04:10:38
Day To Day Tear Off Calendar Printing セリーヌケースコピー Forging Machine
Inserito da Pvc Bathroom Doors With Frame il 25/02/2023 08:26:05
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Inserito da Standard Injection Molding Machine ZX-1100 il 24/02/2023 16:23:20
Countersunk Concrete Bolts ルイヴィトン財布コピー激安代引き Standard Injection Molding Machine ZX-1100
Inserito da Nvr Camera System il 24/02/2023 12:31:28
Inserito da ルイヴィトン財布コピー激安代引き il 24/02/2023 02:24:50
Inserito da Sintered NdFeB Magnetic Properties il 22/02/2023 14:10:34
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Inserito da Waterborne Acrylic Acid Dispersion il 21/02/2023 00:58:44
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Inserito da イヴィトン財布コピー激安代引き il 19/02/2023 18:27:35
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Inserito da ルイヴィトンコピー財布 il 18/02/2023 16:51:27
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Inserito da Diaper Bag Set il 15/02/2023 06:19:46
Inserito da イヴィトン財布コピー激安代引き il 14/02/2023 00:18:48
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Inserito da Sterile Nasopharyngeal Flocked Swab il 10/02/2023 08:07:43
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Inserito da Antipyretic Paste il 10/02/2023 04:25:53
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Inserito da Ptfe Glass Cloth Tape il 06/02/2023 22:37:16
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Inserito da Small Silver Aluminum Box il 02/02/2023 10:53:33
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Inserito da Galvanized Steel Mesh Sheets il 19/01/2023 02:35:08
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Inserito da Household Scrap Wire Shredder il 13/01/2023 16:11:24
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Inserito da イヴィトン財布コピー激安代引き il 05/01/2023 02:21:20
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Inserito da 1/2" Sliding bar with adaptor il 06/12/2022 02:42:30
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Inserito da Steel Fish Tape il 10/11/2022 06:12:55
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Inserito da Vibrating Dildos il 28/10/2022 03:47:25
Inserito da 99.5% 2-Butanone Oxime il 25/10/2022 15:18:06
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Inserito da Stepped Brood Rearing Equipment il 13/10/2022 09:52:15
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Inserito da Intelligent Bulb il 12/10/2022 11:42:56
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Inserito da Home Thermometer il 02/10/2022 09:01:01
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Inserito da Best-Selling Convertible Dining Chair Suppliers - Home Furniture Comfortable soft back leisure velvet fabric bar chair with footrest - Linxi il 22/09/2022 09:59:56
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Inserito da Garra del cucharón del excavador il 16/09/2022 09:17:38
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Inserito da Round Gift Box il 15/09/2022 09:18:49
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Inserito da Gift Pouch il 10/09/2022 11:01:26
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Inserito da Plantes couvre-sol à croissance rapide il 24/08/2022 07:55:22
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Inserito da Pisos de malla abierta de acero il 20/08/2022 21:11:16
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Inserito da Organic Intermediate CAS 25952-53-8 il 18/07/2022 05:51:03
Inserito da Lightweight Backpacking Tent il 17/07/2022 11:49:01
Inserito da Slim Bathroom Cabinet il 12/07/2022 01:59:39
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Inserito da 10AWG Clear Power Cable il 10/07/2022 07:03:45
Inserito da 1mcp Powder And Granular il 07/07/2022 21:17:40
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Inserito da cooling mat for humans il 29/04/2022 15:13:36
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Inserito da Portable Security Light il 29/04/2022 11:38:42
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Inserito da 時計スーパーコピー代引きハミルトン il 23/04/2022 11:28:52
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Inserito da Loredana il 06/06/2012 11:23:00
Mi sembra che la medicina stia correndo a passi da gigante, nell'ambito della cura dei tumori...finalmente questo flagello del XX secolo inizierà a farci sempre meno paura?
Il professore e la dignità della scuola; una battaglia da Don Chisciotte?
EI FU. L'anniversario di un personaggio sicuramente controverso, ma le vestali del politically correct ....
IL KULTURKAMPF DELLA SINISTRA AMERICANA: il mito del piagnisteo che non finisce mai.
GIULIO REGENI: tra verità nascoste e ragione di stato.
Sancte Michael Archangele, defende nos in proelio; la spada dell'arcangelo ci protegga dai moderni iconoclasti!